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Enhanced data sensitivity for investigating brain function

Freedom to choose novel acquisition techniques

The prevalent single-shot EPI acquisition is limited in the type and range of physiological effects it can capture, leading to a failure in identifying the full constellation of neural responses involved in a task. Skope’s technology offers the freedom in sequence design to use MR acquisitions such as spirals. Those can be optimized for sensitivity to the full range of BOLD responses, and can enable the exploration of other physiological effects.

More reliable multi-modal imaging studies

Geometrical misalignment between individuals in an fMRI study caused by the distortions leads to erroneous anatomical allocation of the group-level BOLD signal. Moreover, multi-modal imaging studies can fail due to anatomical inconsistency between different contrasts. Using Skope’s technology, the geometrical congruence can be recovered, enabling reliable group-level analyses and multi-modal imaging studies.

Heightened sensitivity when testing neuroscience hypotheses

Functional MRI exploits changes in MR signal intensity that are small in comparison to temporal signal variation from perturbing sources. The result is a reduced sensitivity towards detecting the BOLD signal. With Skope’s solutions, noise contributions related to perturbations in image encoding can be removed. The gained temporal SNR provides the basis for a reliable detection of the true underlying BOLD response.

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